Article

Transient inhibition of type I interferon enhances CD8 <sup>+</sup> T cell stemness and vaccine protection

2024-06-28

Abstract excerpt

<h4>SUMMARY</h4> Developing vaccines that promote CD8 + T cell memory is a challenge for infectious disease and cancer immunotherapy. TCF-1 + stem cell-like memory T (T SCM ) cells are important determinants of long-lived memory. Yet, the developmental requirements for T SCM formation are unclear. Here, we identify the temporal window for type I interferon (IFN-I) receptor (IFNAR) blockade to drive T SCM cel...

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Literature Corpus work: 1abcaaaf-527e-5b75-b195-c595a673190e
DOI: 10.1101/2024.06.26.600763

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