Article

B cell transcriptomics reveals lasting dysregulation and rapid decline of protective memory after hepatitis C cure

2025-10-24

Abstract excerpt

Chronic hepatitis C (CHC) disrupts host humoral immune response by impairing the timely generation of neutralizing antibody (nAb) and durable immune memory. However, the underlying mechanisms and their reversibility after viral clearance remain poorly defined. Here, through integrated single-cell transcriptomics and antibody repertoire characterization, we show that B cells from CHC patients retain transcriptional...

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Literature Corpus work: 67a8bb5e-39bf-5a2e-9efd-43e743c809fb
DOI: 10.1101/2025.10.24.664545

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