Article

Structural basis of Ku-mediated activation of WRN exonuclease activity

2026-02-16

Abstract excerpt

<title>Abstract</title> <p>Werner (WRN) is the only human RecQ helicase family member with DNA exonuclease activity. WRN promotes genome stability through its functions in DNA replication, repair and telomere maintenance, the deficiency of which presents clinically as Werner syndrome, causing premature aging and cancer predisposition. The main DNA double strand-break sensor Ku70/80 heterodimer (Ku) is a known par...

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Literature Corpus work: 16dcf902-0acf-51dd-93b3-0f320ea0283f
DOI: 10.21203/rs.3.rs-5965979/v1

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