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Article

Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus.

Nucleic acids research - 15 Aug 2002

Karmakar Parimal, Snowden Carey M, Ramsden Dale A, Bohr Vilhelm A

Abstract excerpt

The human Werner syndrome protein, WRN, is a member of the RecQ helicase family and contains 3'-->5' helicase and 3'-->5' exonuclease activities. Recently, we showed that the exonuclease activity of WRN is greatly stimulated by the human Ku heterodimer protein. We have now mapped this interaction physically and functionally. The Ku70 subunit specifically interacts with the N-terminus (amino acids 1-368) of WRN,...

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Share to Antigens, Nuclear
Share to Dimerization
Share to DNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoretic Mobility Shift Assay

Share to Exodeoxyribonucleases

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Share to RecQ Helicases

Share to Werner Syndrome Helicase

Source

Open in PubMed Open full text

Identifiers

PMID: 12177300
DOI: 10.1093/nar/gkf482
PMCID: PMC134248

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus.PMID 12177300Read ↗

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