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Article

The Werner syndrome RECQ helicase as a therapeutic target: new insights.

Expert opinion on therapeutic targets - 1 Jan 2026

Sidorova Julia M, Monnat Raymond J

Abstract excerpt

INTRODUCTION: The WRN gene is mutated in Werner syndrome (WS), a heritable premature aging and cancer predisposition syndrome. Recent work identified WRN as a therapeutic target in a subset of cancers, emphasizing the need to better understand physiologic and cancer-specific roles for WRN that can be leveraged in therapy. AREAS COVERED: We discuss WRN as a caretaker of the genome that can function as a tumor...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41557499
DOI: 10.1080/14728222.2026.2619753

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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