WRN as a Novel Target of Synthetic Lethality: Current Advances and Future Perspectives

Abstract excerpt

Werner syndrome (WS) is an autosomal recessive disorder caused by mutations in the Werner syndrome protein (WRN, also known as RecQ3) gene. As a pivotal member of the RecQ DNA helicase family, WRN facilitates essential processes in DNA replication, recombination, and repair, thus safeguarding genomic stability. In this perspective, we provide a critical analysis of WRN's structural and biological features as well...

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