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Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome Protein

30 Jul 2024

Abstract excerpt

Werner syndrome (WS) is an autosomal recessive disease caused by loss of function of WRN. WS is a segmental progeroid disease and shows early onset or increased frequency of many characteristics of normal aging. WRN possesses helicase, annealing, strand exchange, and exonuclease activities and acts on a variety of DNA substrates, even complex replication and recombination intermediates. Here, we review the...

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PMID: 39125869
DOI: 10.3390/ijms25158300

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