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Article

The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer.

The Journal of biological chemistry - 5 Sept 2008

Compton Sarah A, Tolun Gökhan, Kamath-Loeb Ashwini S, Loeb Lawrence A, Griffith Jack D

Abstract excerpt

Werner syndrome is an inherited disease displaying a premature aging phenotype. The gene mutated in Werner syndrome encodes both a 3' --> 5' DNA helicase and a 3' --> 5' DNA exonuclease. Both WRN helicase and exonuclease preferentially utilize DNA substrates containing alternate secondary structures. By virtue of its ability to resolve such DNA structures, WRN is postulated to prevent the stalling and collapse of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18596042
DOI: 10.1074/jbc.M803370200
PMCID: PMC2528990

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer.PMID 18596042Read ↗

Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome ProteinSemantic proximity Read ↗

Werner syndrome protein contains three structure-specific DNA binding domains.Semantic proximity Read ↗

The Werner Syndrome Protein Is Distinguished from the Bloom Syndrome Protein by Its Capacity to Tightly Bind Diverse DNA StructuresSemantic proximity Read ↗

Werner Syndrome, aging and cancer.Semantic proximity Read ↗

Structural basis of Ku-mediated activation of WRN exonuclease activitySemantic proximity Read ↗

Coordinate Action of the Helicase and 3′ to 5′ Exonuclease of Werner Syndrome ProteinSemantic proximity Read ↗

WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.Semantic proximity Read ↗

Diverse dealings of the Werner helicase/nuclease.Semantic proximity Read ↗

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrestSemantic proximity Read ↗

Werner syndrome protein: functions in the response to DNA damage and replication stress in S-phase.Semantic proximity Read ↗

WRN mutations in Werner syndrome.Semantic proximity Read ↗

Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus.Semantic proximity Read ↗

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