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Article

The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer.

The Journal of biological chemistry - 5 Sept 2008

Compton Sarah A, Tolun Gökhan, Kamath-Loeb Ashwini S, Loeb Lawrence A, Griffith Jack D

Abstract excerpt

Werner syndrome is an inherited disease displaying a premature aging phenotype. The gene mutated in Werner syndrome encodes both a 3' --> 5' DNA helicase and a 3' --> 5' DNA exonuclease. Both WRN helicase and exonuclease preferentially utilize DNA substrates containing alternate secondary structu...

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Share to Dimerization
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Quaternary

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Source

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Identifiers

PMID: 18596042
DOI: 10.1074/jbc.M803370200
PMCID: PMC2528990

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18596042-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer.PMID 18596042Read ↗

Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome ProteinSemantic proximity Read ↗

Werner syndrome protein contains three structure-specific DNA binding domains.Semantic proximity Read ↗

The Werner Syndrome Protein Is Distinguished from the Bloom Syndrome Protein by Its Capacity to Tightly Bind Diverse DNA StructuresSemantic proximity Read ↗

Werner Syndrome, aging and cancer.Semantic proximity Read ↗

Structural basis of Ku-mediated activation of WRN exonuclease activitySemantic proximity Read ↗

Coordinate Action of the Helicase and 3′ to 5′ Exonuclease of Werner Syndrome ProteinSemantic proximity Read ↗

WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.Semantic proximity Read ↗

Diverse dealings of the Werner helicase/nuclease.Semantic proximity Read ↗

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrestSemantic proximity Read ↗

Werner syndrome protein: functions in the response to DNA damage and replication stress in S-phase.Semantic proximity Read ↗

WRN mutations in Werner syndrome.Semantic proximity Read ↗

Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus.Semantic proximity Read ↗

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