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Article

Coordinate Action of the Helicase and 3′ to 5′ Exonuclease of Werner Syndrome Protein

1 Nov 2001

Abstract excerpt

Werner syndrome is a human disorder characterized by premature aging, genomic instability, and abnormal telomere metabolism. The Werner syndrome protein (WRN) is the only known member of the RecQ DNA helicase family that contains a 3' --> 5'-exonuclease. However, it is not known whether both activities coordinate in a biological pathway. Here, we describe DNA structures, forked duplexes containing telomeric...

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Share to Chromosomal and Genetic Variations
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Share to Telomeres, Telomerase, and Senescence

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PMID: 11572872
DOI: 10.1074/jbc.m107548200

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Coordinate Action of the Helicase and 3′ to 5′ Exonuclease of Werner Syndrome ProteinPMID 11572872Read ↗

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Diverse dealings of the Werner helicase/nuclease.Semantic proximity Read ↗

Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome proteinSemantic proximity Read ↗

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Cooperation of DNA-PKcs and WRN helicase in the maintenance of telomeric D-loopsSemantic proximity Read ↗

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