Article
WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.
Aging cell - 1 Aug 2003
Chen Lishan, Huang Shurong, Lee Lin, Davalos Albert, Schiestl Robert H, Campisi Judith, Oshima Junko
Abstract excerpt
Werner syndrome (WS) predisposes patients to cancer and premature aging, owing to mutations in WRN. The WRN protein is a RECQ-like helicase and is thought to participate in DNA double-strand break (DSB) repair by non-homologous end joining (NHEJ) or homologous recombination (HR). It has been previously shown that non-homologous DNA ends develop extensive deletions during repair in WS cells, and that this WS...
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