Article

Systemic Metabolic Rewiring in a Mouse Model of Left Ventricular Hypertrophy

2025-08-18

Abstract excerpt

Left ventricular hypertrophy (LVH) refers to the pathological thickening of the myocardial wall, and is strongly associated with several adverse cardiac outcomes and sudden cardiac death. While the biomechanical drivers of LVH are well established, growing evidence points to a critical role for cardiac and systemic metabolism in modulating hypertrophic remodeling and disease pathogenesis. Despite the efficiency of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1626b201-79a6-5dc2-9972-1963fc663e6a
DOI: 10.1101/2025.08.13.670184

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Systemic Metabolic Rewiring in a Mouse Model of Left Ventricular HypertrophyDOI 10.1101/2025.08.13.670184Read

Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B.Semantic proximity Read

Lipid metabolism drives allele-specific early-stage hypertrophic cardiomyopathySemantic proximity Read

Acute arrhythmias in a long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency mouse model.Semantic proximity Read

Cardiac metabolism and mechanics are altered by genetic loss of lipoprotein triglyceride lipolysis.Semantic proximity Read

Changes in the cardiac metabolome caused by perhexiline treatment in a mouse model of hypertrophic cardiomyopathy.Semantic proximity Read

Hepatic Ketogenesis Attenuates Cardiac Hypertrophy via Metabolic ReprogrammingSemantic proximity Read

A Translational Model of MASLD-Associated HFpEF Defines Mitochondrial Dysfunction and Cardiac Plasticity During Disease Progression and RegressionSemantic proximity Read

Mutation specific impairment of fatty acid and pyruvate oxidation in hypertrophic cardiomyopathy mouse models.Semantic proximity Read

Metabolic remodeling in hypertrophied and failing myocardium: a review.Semantic proximity Read

Obesity and diabetes related disturbances in systemic metabolism induce a cardiometabolic heart failure with preserved ejection fraction phenotype in a combined high-fat, high sucrose diet and streptozotocin mouse modelSemantic proximity Read

A coordinated multiorgan metabolic response contributes to human mitochondrial myopathySemantic proximity Read

Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge.Semantic proximity Read