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Article

Mutation specific impairment of fatty acid and pyruvate oxidation in hypertrophic cardiomyopathy mouse models.

Journal of molecular and cellular cardiology - 1 Aug 2026

Ragavan Mukundan, Knotts Garrett, Thottakara Tilo, Giacalone Anthony G, Eades Hannah, Larson Peder, Abraham M Roselle, Merritt Matthew E

Abstract excerpt

BACKGROUND AND HYPOTHESIS: Hypertrophic cardiomyopathy (HCM) is considered a metabolic disease, but it is unknown whether all sarcomeric protein gene mutations lead to similar derangements of cardiac energy metabolism. Our prior studies showing differences in mitochondrial function in mouse models led us to hypothesize that HCM mutations lead to allele-specific metabolic pathway remodeling. In order to test this...

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Share to Cardiomyopathy, Hypertrophic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42250621
DOI: 10.1016/j.yjmcc.2026.06.005
PMCID: PMC13417912

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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