Article
Partial Liver Kinase B1 (LKB1) Deficiency Promotes Diastolic Dysfunction, De Novo Systolic Dysfunction, Apoptosis, and Mitochondrial Dysfunction With Dietary Metabolic Challenge.
Journal of the American Heart Association - 31 Dec 2015
Miller Edward J, Calamaras Timothy, Elezaby Aly, Sverdlov Aaron, Qin Fuzhong, Luptak Ivan, Wang Ke, Sun Xinxin, Vijay Andrea, Croteau Dominique, Bachschmid Markus, Cohen Richard A, Walsh Kenneth, Colucci Wilson S
Abstract excerpt
BACKGROUND: Myocardial hypertrophy and dysfunction are key features of metabolic heart disease due to dietary excess. Metabolic heart disease manifests primarily as diastolic dysfunction but may progress to systolic dysfunction, although the mechanism is poorly understood. Liver kinase B1 (LKB1) is a key activator of AMP-activated protein kinase and possibly other signaling pathways that oppose myocardial...
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