Article

Geometry-Constrained Prediction of Catalytically Competent Kinase Domains Across the Human Kinome

2025-11-04

Abstract excerpt

<h4>Summary</h4> Understanding cellular signaling networks benefits from accurate structural modeling of protein kinases across their different functional states. However, most human kinases lack experimentally determined active-state structures, and existing computational methods often fail to reliably predict catalytically competent conformations. Here, we present a geometry-constrained modeling framework based...

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Literature Corpus work: 160d47f9-f666-5c82-9e39-e556f712c3d0
DOI: 10.1101/2025.11.03.686188

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