Article

KinConfBench: A Curated Benchmark for Cofolding Models on Kinase Conformational States

2026-04-10

Abstract excerpt

Protein kinases are critical drug targets, requiring therapeutics that can modulate their active and inactive conformational states. While cofolding models can generate global folds directly from kinase sequences and ligand SMILES strings, these models have not yet been tested on their ability to recover ligand induced-fit conformational states of the kinase proteins. Here, we introduce KinConfBench, a curated ben...

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Literature Corpus work: ea72fa3d-a574-596e-bfc8-985551407558
DOI: 10.64898/2026.04.07.716788

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