Article
A structural atlas of kinases inhibited by clinically approved drugs.
Methods in enzymology - 1 Jan 2014
Wang Qi, Zorn Julie A, Kuriyan John
Abstract excerpt
The aberrant activation of protein kinases is associated with many human diseases, most notably cancer. Due to this link between kinase deregulation and disease progression, kinases are one of the most targeted protein families for small-molecule inhibition. Within the last 15 years, the U.S. Food and Drug Administration has approved over 20 small-molecule inhibitors of protein kinases for use in the clinic....
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