Article

Generalizable Protein Dynamics in Kinases: Physics is the key

2025-03-11

Abstract excerpt

Kinases play crucial roles in signaling pathways across oncology, inflammation, and neurodegenerative diseases. Historically, their conformational states have been defined by the DFG motif: DFG in and DFG out . However, this binary paradigm overlooks the broader conformational heterogeneity of apo kinases, which encompasses multiple metastable states within an expanded DFG-Phe ensemble. We introduced a novel nom...

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Literature Corpus work: 6470b439-e1cd-5814-b076-d0a91a78f517
DOI: 10.1101/2025.03.06.641878

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