Article

AlphaFold2 models of the active form of all 437 catalytically competent human protein kinase domains

2023-07-25

Abstract excerpt

<h4> Abstract </h4> Humans have 437 catalytically competent protein kinase domains with the typical kinase fold, similar to the structure of Protein Kinase A (PKA). Only 155 of these kinases are in the Protein Data Bank in their active form. The active form of a kinase must satisfy requirements for binding ATP, magnesium, and substrate. From structural bioinformatics analysis of 40 unique substrate-bound kinases...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 95737631-04a0-553c-bc71-4e5e9689321d
DOI: 10.1101/2023.07.21.550125

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

AlphaFold2 models of the active form of all 437 catalytically competent human protein kinase domainsDOI 10.1101/2023.07.21.550125Read

Defining the Active Conformation of Typical Protein Kinase Domains from Substrate-Bound PDB Structures Enables Active-State AlphaFold2 Models for All 437 Human Catalytic Protein KinasesSemantic proximity Read

Geometry-Constrained Prediction of Catalytically Competent Kinase Domains Across the Human KinomeSemantic proximity Read

KinFams: De-Novo Classification of Protein Kinases Using CATH Functional UnitsSemantic proximity Read

Kinematic analysis of kinases and their oncogenic mutations - Kinases and their mutation kinematic analysis.Semantic proximity Read

Conservation and divergence in the allosteric architectures of five human protein kinasesSemantic proximity Read

A structure-based tool to interpret the significance of kinase mutations in clinical next generation sequencing in cancerSemantic proximity Read

Towards a structurally resolved human protein interaction network.Semantic proximity Read

Emerging roles of the αC-β4 loop in protein kinase structure, function, evolution, and disease.Semantic proximity Read

Applying multi-state modeling using AlphaFold2 for kinases and its application for ensemble screeningSemantic proximity Read

In vitro Kinase-to-Phosphosite database (iKiP-DB) predicts kinase activity in phosphoproteomic datasetsSemantic proximity Read

A resource for exploring the understudied human kinome for research and therapeutic opportunitiesSemantic proximity Read

A structural atlas of kinases inhibited by clinically approved drugs.Semantic proximity Read