Article

Integrative machine learning predicts activating kinase mutations for precision oncology

2025-10-15

Abstract excerpt

Kinases are enzymes that catalyze phosphorylation and play crucial roles in a myriad of cellular regulatory processes and hemostasis. Patient-specific genetic mutations that aberrantly activate kinases can profoundly influence cancer progression and alter drug efficacy. Predicting the impact of such missense mutations across the human kinome on protein function and cellular signaling is therefore a critical step t...

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Identifiers and source

Literature Corpus work: 998c9fc2-deff-5a0e-a700-f64ec098f30e
DOI: 10.1101/2025.10.14.682355

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