Article

Clinically-relevant T cell expansion protocols activate distinct cellular metabolic programs and phenotypes

2021-08-26

Abstract excerpt

Ex vivo expansion conditions used to generate T cells for immunotherapy are thought to adopt metabolic phenotypes that impede therapeutic efficacy in vivo . The comparison of five different culture media used for clinical T cell expansion revealed unique optima based on different output variables including proliferation, differentiation, function, activation and mitochondrial phenotypes. T cells adapted their met...

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Literature Corpus work: 5ba6a2bc-392e-5bd1-bd7c-401e62e65546
DOI: 10.1101/2021.08.24.457536

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