Article

Glutamine-driven mTORC1 activity enforces glycolytic bias, hyperactivation and aberrant proliferation in T cells in chronic B-cell leukemia

2026-06-10

Abstract excerpt

<h4>Summary</h4> T-cell metabolic dysfunction is increasingly recognized as a hallmark of poor antitumor responses. Still, how distinct metabolic states shape T-cell function and which signaling pathways sustain them remains unclear. Here, we show that T cells from patients with chronic lymphocytic leukemia (CLL) adopt a hyperactivated phenotype characterized by high cytokine production, aberrant proliferation an...

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Literature Corpus work: 776c269d-e8f6-5eae-b548-3f7198f24b55
DOI: 10.64898/2026.06.09.731122

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