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Clinically relevant T cell expansion media activate distinct metabolic programs uncoupled from cellular function

15 Feb 2022

Abstract excerpt

Ex vivo expansion conditions used to generate T cells for immunotherapy are thought to adopt metabolic phenotypes that impede therapeutic efficacy in vivo . The comparison of five different culture media used for clinical T cell expansion revealed unique optima based on different output variables, including proliferation, differentiation, function, activation, and mitochondrial phenotypes. The extent of...

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PMID: 35284590
DOI: 10.1016/j.omtm.2022.02.004

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