Article

Autophagy disruption primes CAR-T cell metabolism for sustained rejection of ovarian tumors

2025-10-10

Abstract excerpt

<h4>ABSTRACT</h4> T-cell based immunotherapies such as chimeric antigen receptor T (CAR-T) cell therapy face substantial hurdles when confronting solid tumors such as ovarian cancer, where metabolic constraints in the tumor microenvironment limit T cell infiltration and function. In particular, T cells exposed to nutrient deprivation and hypoxia upregulate autophagy, a lysosomal degradation pathway that negativel...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7398d820-4a58-51e3-9dd7-4622ec8543c0
DOI: 10.1101/2025.10.09.681473

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Autophagy disruption primes CAR-T cell metabolism for sustained rejection of ovarian tumorsDOI 10.1101/2025.10.09.681473Read

Immunogenetic metabolomics revealed key enzymes that modulate CAR-T metabolism and functionSemantic proximity Read

Mechanisms of T‑cell metabolic reprogramming in the microenvironment of acute myeloid leukemia and its therapeutic potential (Review)Semantic proximity Read

A Metabolism Toolbox for CAR T TherapySemantic proximity Read

Metabolic reprogramming in the tumour microenvironment: a hallmark shared by cancer cells and T lymphocytes.Semantic proximity Read

Altered cancer metabolism and implications for next-generation CAR T-cell therapiesSemantic proximity Read

Palbociclib and Rapamycin pretreatment boosted the persistence and functionality of CAR-T cells in solid tumors through metabolic reprogrammingSemantic proximity Read

Fueling CARs: metabolic strategies to enhance CAR T-cell therapySemantic proximity Read

Dual targeting of glutamine metabolism and lysosomal function in eliminating drug-tolerant KRAS-mutant cancer cells.Semantic proximity Read

Metabolic reprogramming of the tumor microenvironment to enhance immunotherapySemantic proximity Read

Metabolic armouring of CAR and TCR T cellsSemantic proximity Read

Metabolic priming of GD2 <i>TRAC</i> -CAR T cells during manufacturing promotes memory phenotypes while enhancing persistenceSemantic proximity Read

Acetyl-CoA Carboxylase Obstructs CD8 <sup>+</sup> T-Cell Lipid Utilization and Energy Synthesis in the Tumor MicroenvironmentSemantic proximity Read