Article

Intra-tumoral epigenetic heterogeneity and aberrant molecular clocks in hepatocellular carcinoma

2021-03-24

Abstract excerpt

<h4>ABSTRACT</h4> There is limited understanding of the epigenetic drivers of tumor evolution in hepatocellular carcinoma (HCC). Here we characterize the epigenetic contribution of methylation to intra-tumoral heterogeneity (mITH) using regional enhanced reduced-representation bisulfite sequencing DNA methylation data from 47 early stage, treatment-naive HCC biopsies across 9 patients by quantifying regional diff...

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Literature Corpus work: 15cd526c-e6e8-5e24-a927-fb237b981ca0
DOI: 10.1101/2021.03.22.21253654

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