DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation.

doi:10.1038/s41467-021-25661-w

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Article

DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation.

Nature communications - 13 Sept 2021

Batra Rajbir Nath, Lifshitz Aviezer, Vidakovic Ana Tufegdzic, Chin Suet-Feung, Sati-Batra Ankita, Sammut Stephen-John, Provenzano Elena, Ali H Raza, Dariush Ali, Bruna Alejandra, Murphy Leigh, Purushotham Arnie, Ellis Ian, Green Andrew, Garrett-Bakelman Francine E, Mason Chris, Melnick Ari, Aparicio Samuel A J R, Rueda Oscar M, Tanay Amos, Caldas Carlos

Abstract excerpt

DNA methylation is aberrant in cancer, but the dynamics, regulatory role and clinical implications of such epigenetic changes are still poorly understood. Here, reduced representation bisulfite sequencing (RRBS) profiles of 1538 breast tumors and 244 normal breast tissues from the METABRIC cohort are reported, facilitating detailed analysis of DNA methylation within a rich context of genomic, transcriptional, and...

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PMID: 34518533
DOI: 10.1038/s41467-021-25661-w
PMCID: PMC8437946

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