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Article

Epigenetic heterogeneity hotspots in human liver disease progression

19 Jul 2024

Abstract excerpt

BACKGROUND AND AIMS: Disruption of the epigenome is a hallmark of human disease, including liver cirrhosis and HCC. While genetic heterogeneity is an established effector of pathologic phenotypes, epigenetic heterogeneity is less well understood. Environmental exposures alter the liver-specific DNA methylation landscape and influence the onset of liver cancer. Given that currently available treatments are unable...

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PMID: 39028883
DOI: 10.1097/hep.0000000000001023

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