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Article

Intratumoral Heterogeneity of the Epigenome.

Cancer cell - 11 Apr 2016

Mazor Tali, Pankov Aleksandr, Song Jun S, Costello Joseph F

Abstract excerpt

Investigation into intratumoral heterogeneity (ITH) of the epigenome is in a formative stage. The patterns of tumor evolution inferred from epigenetic ITH and genetic ITH are remarkably similar, suggesting widespread co-dependency of these disparate mechanisms. The biological and clinical relevance of epigenetic ITH are becoming more apparent. Rare tumor cells with unique and reversible epigenetic states may...

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Identifiers

PMID: 27070699
DOI: 10.1016/j.ccell.2016.03.009
PMCID: PMC4852161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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