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DNA Methylation Signatures Reveal the Diversity of Processes Remodeling Hepatocellular Carcinoma Methylomes.

Hepatology (Baltimore, Md.) - 1 Aug 2021

Meunier Léa, Hirsch Théo Z, Caruso Stefano, Imbeaud Sandrine, Bayard Quentin, Roehrig Amélie, Couchy Gabrielle, Nault Jean-Charles, Llovet Josep M, Blanc Jean-Frédéric, Calderaro Julien, Zucman-Rossi Jessica, Letouzé Eric

Abstract excerpt

BACKGROUND AND AIMS: DNA methylation patterns are highly rearranged in HCCs. However, diverse sources of variation are intermingled in cancer methylomes, precluding the precise characterization of underlying molecular mechanisms. We developed a computational framework (methylation signature analysis with independent component analysis [MethICA]) leveraging independent component analysis to disentangle the diverse...

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PMID: 33713365
DOI: 10.1002/hep.31796

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