Article
A multimodal atlas of hepatocellular carcinoma reveals convergent evolutionary paths and 'bad apple' effect on clinical trajectory.
Journal of hepatology - 1 Oct 2024
Chen Jianbin, Kaya Neslihan Arife, Zhang Ying, Kendarsari Raden Indah, Sekar Karthik, Lee Chong Shay, Seshachalam Veerabrahma Pratap, Ling Wen Huan, Jin Phua Cheryl Zi, Lai Hannah, Yang Hechuan, Lu Bingxin, Lim Jia Qi, Ma Siming, Chew Sin Chi, Chua Khi Pin, Santiago Alvarez Jacob Josiah, Wu Lingyan, Ooi London, Yaw-Fui Chung Alexander, Cheow Peng Chung, Kam Juinn Huar, Wei-Chieh Kow Alfred, Ganpathi Iyer Shridhar, Bunchaliew Chairat, Thammasiri Jidapa, Koh Peng Soon, Bee-Lan Ong Diana, Lim Jasmine, de Villa Vanessa H, Dela Cruz Rouchelle D, Loh Tracy Jiezhen, Wan Wei Keat, Leow Wei Qiang, Yang Yi, Liu Jin, Skanderup Anders Jacobsen, Pang Yin Huei, Ting Soon Gwyneth Shook, Madhavan Krishnakumar, Kiat-Hon Lim Tony, Bonney Glenn, Goh Brian K P, Chew Valerie, Dan Yock Young, Toh Han Chong, Sik-Yin Foo Roger, Tam Wai Leong, Zhai Weiwei, Kah-Hoe Chow Pierce
Abstract excerpt
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is a highly fatal cancer characterized by high intra-tumor heterogeneity (ITH). A panoramic understanding of its tumor evolution, in relation to its clinical trajectory, may provide novel prognostic and treatment strategies. METHODS: Through the Asia-Pacific Hepatocellular Carcinoma trials group (NCT03267641), we recruited one of the largest prospective cohorts of...
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