Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Initiation of aberrant DNA methylation patterns and heterogeneity in precancerous lesions of human hepatocellular cancer

6 Jan 2017

Abstract excerpt

While intratumor heterogeneity contributes to disease progression, metastasis, and resistance to chemotherapy, it also provides a route to understanding the evolution and drivers of disease. Defects in epigenetic landscapes are intimately linked to pathogenesis of a variety of human diseases, with epigenetic deregulation promoting tumorigenesis. Understanding epigenetic heterogeneity is crucial in hepatocellular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Epigenetics and DNA Methylation
Share to Ferroptosis and cancer prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28059585
DOI: 10.1080/15592294.2016.1277297

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Initiation of aberrant DNA methylation patterns and heterogeneity in precancerous lesions of human hepatocellular cancerPMID 28059585Read ↗

Epigenetic heterogeneity hotspots in human liver disease progressionSemantic proximity Read ↗

Intra-tumoral epigenetic heterogeneity and aberrant molecular clocks in hepatocellular carcinomaSemantic proximity Read ↗

Genetic and Epigenetic Heterogeneity in Normal Liver Homeostasis and Its Implications for Liver Disease and Hepatocellular Cancer.Semantic proximity Read ↗

DNA Methylation Signatures Reveal the Diversity of Processes Remodeling Hepatocellular Carcinoma Methylomes.Semantic proximity Read ↗

DNA methylation variability defines a fundamental dimension of tumor epigenomes linked to genomic instability, tumor aggressiveness, and clinical outcomesSemantic proximity Read ↗

Hepatocellular Carcinoma Displays Distinct DNA Methylation Signatures with Potential as Clinical PredictorsSemantic proximity Read ↗

Epigenetic modifications precede molecular alterations and drive human hepatocarcinogenesisSemantic proximity Read ↗

Genetic Landscape of Multistep HepatocarcinogenesisSemantic proximity Read ↗

DNA methylation fingerprint of hepatocellular carcinoma from tissue and liquid biopsiesSemantic proximity Read ↗

DNA methylation fingerprint for the diagnosis and monitoring of hepatocellular carcinoma from tissue and liquid biopsiesSemantic proximity Read ↗

Genomic landscape of hepatocarcinogenesis.Semantic proximity Read ↗

Comprehensive review and updated analysis of DNA methylation in hepatocellular carcinoma: From basic research to clinical applicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.