Intratumoral heterogeneity and clonal evolution in liver cancer.

doi:10.1038/s41467-019-14050-z

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Article

Intratumoral heterogeneity and clonal evolution in liver cancer.

Nature communications - 15 Jan 2020

Losic Bojan, Craig Amanda J, Villacorta-Martin Carlos, Martins-Filho Sebastiao N, Akers Nicholas, Chen Xintong, Ahsen Mehmet E, von Felden Johann, Labgaa Ismail, DʹAvola Delia, Allette Kimaada, Lira Sergio A, Furtado Glaucia C, Garcia-Lezana Teresa, Restrepo Paula, Stueck Ashley, Ward Stephen C, Fiel Maria I, Hiotis Spiros P, Gunasekaran Ganesh, Sia Daniela, Schadt Eric E, Sebra Robert, Schwartz Myron, Llovet Josep M, Thung Swan, Stolovitzky Gustavo, Villanueva Augusto

Abstract excerpt

Clonal evolution of a tumor ecosystem depends on different selection pressures that are principally immune and treatment mediated. We integrate RNA-seq, DNA sequencing, TCR-seq and SNP array data across multiple regions of liver cancer specimens to map spatio-temporal interactions between cancer and immune cells. We investigate how these interactions reflect intra-tumor heterogeneity (ITH) by correlating regional...

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PMID: 31941899
DOI: 10.1038/s41467-019-14050-z
PMCID: PMC6962317

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