Article

Nascent prostate cancer heterogeneity drives evolution and resistance to intense hormonal therapy

2020-09-30

Abstract excerpt

<h4>ABSTRACT</h4> Localized prostate cancer is distinctively characterized by intratumoral heterogeneity, and tumors with more complex evolutionary paths display more aggressive characteristics. In clinical trials of intense neoadjuvant androgen deprivation therapy (inADT), patients with complete or near-complete responses experience durable remissions. However, the molecular characteristics distinguishing excepti...

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Literature Corpus work: 15a292a2-7e48-5efa-8b9f-66853645297b
DOI: 10.1101/2020.09.29.20199711

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