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Integrated analysis of single-cell and bulk transcriptomes uncovers clinically relevant molecular subtypes in human prostate cancer

1 Jan 2025

Abstract excerpt

ObjectiveProstate cancer (PCa) is a complex disease characterized by diverse cellular ecosystems within the tumor microenvironment (TME) and high tumor heterogeneity, which challenges clinically stratified management and reinforces the need for novel strategies to fight against castration-resistant PCa (CRPC). MethodsWe performed single-cell RNA sequencing (scRNA-seq) on 10 untreated primary PCa tissues and...

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PMID: 40078560
DOI: 10.21147/j.issn.1000-9604.2025.01.07

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