Genomic evolution shapes prostate cancer disease type.

doi:10.1016/j.xgen.2024.100511

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Article

Genomic evolution shapes prostate cancer disease type.

Cell genomics - 13 Mar 2024

Woodcock Dan J, Sahli Atef, Teslo Ruxandra, Bhandari Vinayak, Gruber Andreas J, Ziubroniewicz Aleksandra, Gundem Gunes, Xu Yaobo, Butler Adam, Anokian Ezequiel, Pope Bernard J, Jung Chol-Hee, Tarabichi Maxime, Dentro Stefan C, Farmery J Henry R, Van Loo Peter, Warren Anne Y, Gnanapragasam Vincent, Hamdy Freddie C, Bova G Steven, Foster Christopher S, Neal David E, Lu Yong-Jie, Kote-Jarai Zsofia, Fraser Michael, Bristow Robert G, Boutros Paul C, Costello Anthony J, Corcoran Niall M, Hovens Christopher M, Massie Charlie E, Lynch Andy G, Brewer Daniel S, Eeles Rosalind A, Cooper Colin S, Wedge David C

Abstract excerpt

The development of cancer is an evolutionary process involving the sequential acquisition of genetic alterations that disrupt normal biological processes, enabling tumor cells to rapidly proliferate and eventually invade and metastasize to other tissues. We investigated the genomic evolution of prostate cancer through the application of three separate classification methods, each designed to investigate a...

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Identifiers

PMID: 38428419
DOI: 10.1016/j.xgen.2024.100511
PMCID: PMC10943594

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