Article
Tumor architecture and emergence of strong genetic alterations are bottlenecks for clonal evolution in primary prostate cancer.
Cell systems - 20 Nov 2024
Kreten Florian, Büttner Reinhard, Peifer Martin, Harder Christian, Hillmer Axel M, Abedpour Nima, Bovier Anton, Tolkach Yuri
Abstract excerpt
Prostate cancer (PCA) exhibits high levels of intratumoral heterogeneity. In this study, we developed a mathematical model to study the growth and genetic evolution of PCA. We explored the possible evolutionary patterns and demonstrated that tumor architecture represents a major bottleneck for divergent clonal evolution. Early consecutive acquisition of strong genetic alterations serves as a proxy for the...
Topics
- Humans
- Prostatic Neoplasms
- Male
- Clonal Evolution
- Models, Theoretical
- Mutation
- High-Throughput Nucleotide Sequencing