Article

Recurrent intra-tumour heterogeneity is a hallmark of metastatic prostate cancer

2025-11-25

Abstract excerpt

<title>Abstract</title> <p> The evolution from low grade to metastatic tumour is a major determinant of cancer mortality. Cancer evolution involves a complex interplay between intrinsic genetics and transcriptional alterations and the microenvironment. To define mechanisms underpinning metastatic development, we focused on metastatic castration-resistant prostate cancer (mCRPC) and employed single-cell multi-omi...

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Literature Corpus work: f261839f-cd4a-5632-a52d-ba4299bead8f
DOI: 10.21203/rs.3.rs-7015699/v1

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