Article
The Evolutionary Landscape of Localized Prostate Cancers Drives Clinical Aggression.
Cell - 3 May 2018
Espiritu Shadrielle Melijah G, Liu Lydia Y, Rubanova Yulia, Bhandari Vinayak, Holgersen Erle M, Szyca Lesia M, Fox Natalie S, Chua Melvin L K, Yamaguchi Takafumi N, Heisler Lawrence E, Livingstone Julie, Wintersinger Jeff, Yousif Fouad, Lalonde Emilie, Rouette Alexandre, Salcedo Adriana, Houlahan Kathleen E, Li Constance H, Huang Vincent, Fraser Michael, van der Kwast Theodorus, Morris Quaid D, Bristow Robert G, Boutros Paul C
Abstract excerpt
The majority of newly diagnosed prostate cancers are slow growing, with a long natural life history. Yet a subset can metastasize with lethal consequences. We reconstructed the phylogenies of 293 localized prostate tumors linked to clinical outcome data. Multiple subclones were detected in 59% of patients, and specific subclonal architectures associate with adverse clinicopathological features. Early tumor...
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