Article
Single-Cell RNA-seq Reveals a Developmental Hierarchy Super-Imposed Over Subclonal Evolution in the Cellular Ecosystem of Prostate Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 May 2022
Ge Guangzhe, Han Yang, Zhang Jianye, Li Xinxin, Liu Xiaodan, Gong Yanqing, Lei Zhentao, Wang Jie, Zhu Weijie, Xu Yangyang, Peng Yiji, Deng Jianhua, Zhang Bao, Li Xuesong, Zhou Liqun, He Huiying, Ci Weimin
Abstract excerpt
Prostate cancer (PCa) is a complex disease. An ongoing accumulation of mutations results in increased genetic diversity, with the tumor acquiring distinct subclones. However, non-genetic intra-tumoral heterogeneity, the cellular differentiation state and the interplay between subclonal evolution and transcriptional heterogeneity are poorly understood. Here, the authors perform single-cell RNA sequencing from 14...
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