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Improved Immune Responses and Tuberculosis Protection by Aerosol Vaccination with recombinant BCG expressing ESX-1 from <i>Mycobacterium marinum</i>

2025-09-18

Abstract excerpt

The currently licensed anti-tuberculosis (TB) vaccine, Mycobacterium bovis BCG, provides limited protection against pulmonary TB in adolescents and adults, the main cause of TB transmission and mortality. To obtain an improved BCG-based vaccine candidate with increased immune signaling but still low virulence, we have previously generated a recombinant BCG strain named BCG::ESX-1 Mmar , which is heterologously e...

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Identifiers and source

Literature Corpus work
159c6bef-e81c-5a3e-8cdd-a4297783e028
DOI
10.1101/2025.09.18.677039
Open publication

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