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<i>In vivo</i> antigen expression regulates CD4 T cell differentiation and vaccine efficacy against <i>Mycobacterium tuberculosis</i> infection

2021-02-03

Abstract excerpt

New vaccines are urgently needed against Mycobacterium tuberculosis (Mtb), which kills more than 1.4 million people each year. CD4 T cell differentiation is a key determinant of protective immunity against Mtb, but it is not fully understood how host-pathogen interactions shape individual antigen-specific T cell populations and their protective capacity. Here, we investigated the immunodominant Mtb antigen, MPT70...

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Identifiers and source

Literature Corpus work
e956bd9b-77d6-5af8-a138-6b137bbc5e28
DOI
10.1101/2021.02.02.429488
Open publication

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<i>In vivo</i> antigen expression regulates CD4 T cell differentiation and vaccine efficacy against <i>Mycobacterium tuberculosis</i> infectionDOI 10.1101/2021.02.02.429488
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