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Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection

1 Mar 2017

Abstract excerpt

Recent insights into the mechanisms by which Mycobacterium tuberculosis , the etiologic agent of human tuberculosis, is recognized by cytosolic nucleotide sensors have opened new avenues for rational vaccine design. The only licensed anti-tuberculosis vaccine, Mycobacterium bovis BCG, provides limited protection. A feature of BCG is the partial deletion of the ESX-1 type VII secretion system, which governs...

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PMID: 28297677
DOI: 10.1016/j.celrep.2017.02.057

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