Article

Attenuated <i>Mycobacterium tuberculosis</i> Vaccine Protection in a Low Dose Murine Challenge Model

2023-03-18

Abstract excerpt

Bacillus Calmette–Guérin (BCG) remains the only clinically approved tuberculosis (TB) vaccine despite limited efficacy. Preclinical studies of next generation TB vaccines have typically used a murine aerosol challenge model that employs a high supraphysiologic challenge dose. Here we show that the protective efficacy of a live attenuated Mycobacterium tuberculosis (Mtb) vaccine candidate ΔLprG markedly exceeds th...

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Identifiers and source

Literature Corpus work: 1566d891-b43b-567f-8a76-49c0678f03e2
DOI: 10.1101/2023.03.17.533226

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