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BCG Vaccines: Their mechanisms of attenuation and impact on safety and protective efficacy

1 Feb 2009

Abstract excerpt

Mycobacterium bovis Bacille Calmette-Guérin (BCG) was developed as an attenuated live vaccine for tuberculosis control nearly a century ago. Despite being the most widely used vaccine in human history, the mechanisms of attenuation of BCG remain poorly understood. BCG is not a single organism, but comprises a number of substrains that differ in genotypes and phenotypes. The impacts of these differences on BCG...

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PMID: 19164935
DOI: 10.4161/hv.5.2.7210

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