Article

A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilizing immunity against SARS-CoV-2 infection in mice

2020-12-10

Abstract excerpt

<h4>ABSTRACT</h4> Global control of COVID-19 requires broadly accessible vaccines that are effective against SARS-CoV-2 variants. In this report, we exploit the immunostimulatory properties of bacille Calmette-Guérin (BCG), the existing tuberculosis vaccine, to deliver a vaccination regimen with potent SARS-CoV-2-specific protective immunity. Combination of BCG with a stabilized, trimeric form of SARS-CoV-2 spike...

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Literature Corpus work: 48d512a6-448f-5337-aeb9-51c13ab47d16
DOI: 10.1101/2020.12.10.419044

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