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Mycobacterial EsxG·EsxH (TB9.8·TB10.4) peptides as a subunit vaccine to booster BCG vaccination in an experimental model of pulmonary Tuberculosis

2024-12-12

Abstract excerpt

The attenuated Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccine is currently the only validated vaccine against tuberculosis (TB). In a previous study, we conducted an in-silico selection of four peptides (G1, G2, H1, and H2) derived from the mycobacterial protein antigens TB10.9·TB10.4 (EsxG·EsxH). Bioinformatic analysis and molecular dynamic simulations predicted these epitopes could be loaded into a...

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Literature Corpus work
2096d583-ec18-5b7e-b501-57588e19342c
DOI
10.1101/2024.12.12.628125
Open publication

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Mycobacterial EsxG·EsxH (TB9.8·TB10.4) peptides as a subunit vaccine to booster BCG vaccination in an experimental model of pulmonary TuberculosisDOI 10.1101/2024.12.12.628125
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