Article

Human PRPS1 filaments stabilize allosteric sites to regulate activity

2022-06-27

Abstract excerpt

The universally conserved enzyme phosphoribosyl pyrophosphate synthetase (PRPS) assembles filaments in evolutionarily diverse organisms. PRPS is a key regulator of nucleotide metabolism, and mutations in the human enzyme PRPS1 lead to a spectrum of diseases. Here, we determine structures of PRPS1 filaments in active and inhibited states, with fixed assembly contacts accommodating both conformations. The conserved...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 159a9334-79b1-59eb-b00d-934cd173b0cd
DOI: 10.1101/2022.06.27.496812

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human PRPS1 filaments stabilize allosteric sites to regulate activityDOI 10.1101/2022.06.27.496812Read

Human PRPS1 filaments stabilize allosteric sites to regulate activity.Semantic proximity Read

Structural basis of human PRPS2 filamentsSemantic proximity Read

CTP Drives Human CTPS1 FilamentationSemantic proximity Read

B56δ long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations.Semantic proximity Read

Crystal and EM structures of human phosphoribosyl pyrophosphate synthase I (PRS1) provide novel insights into the disease-associated mutations.Semantic proximity Read

Light-sensitive phosphorylation regulates enzyme activity and filament assembly of human IMPDH1 retinal splice variantsSemantic proximity Read

Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzymeSemantic proximity Read

IMPDH1 retinal variants control filament architecture to tune allosteric regulationSemantic proximity Read

Phosphoribosylpyrophosphate synthetase superactivity and recurrent infections is caused by a p.Val142Leu mutation in PRS-I.Semantic proximity Read

Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants.Semantic proximity Read

Structural basis of dynamic P5CS filaments.Semantic proximity Read

Product-stabilized filamentation by human glutamine synthetase allosterically tunes metabolic activitySemantic proximity Read