Article

CTP Drives Human CTPS1 Filamentation

2025-02-27

Abstract excerpt

CTP synthase (CTPS) is a key enzyme in de novo CTP synthesis, playing a critical role in nucleotide metabolism and cellular proliferation. Human CTPS1 (hCTPS1), one of the two CTPS isoforms, is essential for immune responses and is highly expressed in proliferating cells, making it a promising therapeutic target for immune-related diseases and cancer. Despite its importance, the regulatory mechanisms governing hC...

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Literature Corpus work: d2ba2ca2-ac5f-59a3-8219-902dd49c8483
DOI: 10.1101/2025.02.22.639624

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