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Article

IMPDH1 retinal variants control filament architecture to tune allosteric regulation

2021-08-04

Abstract excerpt

<h4>ABSTRACT</h4> IMP dehydrogenase (IMPDH), a key regulatory enzyme in purine nucleotide biosynthesis, dynamically assembles filaments in response to changes in metabolic demand. Humans have two isoforms: IMPDH2 filaments reduce sensitivity to feedback inhibition by the downstream product GTP, while IMPDH1 assembly remains uncharacterized. IMPDH1 plays a unique role in retinal metabolism, and point mutants cause...

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Identifiers and source

Literature Corpus work
65ad33e4-fc3b-5f9d-b9a9-bb868dfb2ceb
DOI
10.1101/2021.08.03.454821
Open publication

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IMPDH1 retinal variants control filament architecture to tune allosteric regulationDOI 10.1101/2021.08.03.454821
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