Article

Light-sensitive phosphorylation regulates enzyme activity and filament assembly of human IMPDH1 retinal splice variants

2023-09-21

Abstract excerpt

<h4>ABSTRACT</h4> Inosine monophosphate dehydrogenase (IMPDH) is the rate-limiting enzyme in de novo guanosine triphosphate (GTP) synthesis and is controlled by feedback inhibition and allosteric regulation. IMPDH assembles into micron-scale filaments in cells, which desensitizes the enzyme to feedback inhibition by GTP and boosts nucleotide production. The vertebrate retina expresses two tissue-specific splice...

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Literature Corpus work: 9cc6f03c-f1b9-5a92-8778-e46b4cc46407
DOI: 10.1101/2023.09.21.558867

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