Article
B56δ long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan's syndrome mutations.
Proceedings of the National Academy of Sciences of the United States of America - 2 Jan 2024
Wu Cheng-Guo, Balakrishnan Vijaya K, Merrill Ronald A, Parihar Pankaj S, Konovolov Kirill, Chen Yu-Chia, Xu Zhen, Wei Hui, Sundaresan Ramya, Cui Qiang, Wadzinski Brian E, Swingle Mark R, Musiyenko Alla, Chung Wendy K, Honkanen Richard E, Suzuki Aussie, Huang Xuhui, Strack Stefan, Xing Yongna
Abstract excerpt
Intrinsically disordered regions (IDR) and short linear motifs (SLiMs) play pivotal roles in the intricate signaling networks governed by phosphatases and kinases. B56δ (encoded by PPP2R5D) is a regulatory subunit of protein phosphatase 2A (PP2A) with long IDRs that harbor a substrate-mimicking SLiM and multiple phosphorylation sites. De novo missense mutations in PPP2R5D cause intellectual disabilities (ID),...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.